Dorsal root ganglia in Friedreich ataxia: satellite cell proliferation and inflammation
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چکیده
منابع مشابه
Friedreich ataxia: metal dysmetabolism in dorsal root ganglia
BACKGROUND Friedreich ataxia (FA) causes distinctive lesions of dorsal root ganglia (DRG), including neuronal atrophy, satellite cell hyperplasia, and absorption of dying nerve cells into residual nodules. Two mechanisms may be involved: hypoplasia of DRG neurons from birth and superimposed iron (Fe)- and zinc (Zn)-mediated oxidative injury. This report presents a systematic analysis of DRG in ...
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Friedreich ataxia (FRDA), the most common recessive ataxia, is characterized by degeneration of the large sensory neurons of the spinal cord and cardiomyopathy. It is caused by severely reduced levels of frataxin, a mitochondrial protein involved in iron-sulfur cluster (ISC) biosynthesis. Through a spatiotemporally controlled conditional gene-targeting approach, we have generated two mouse mode...
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Bodies with the morphologic and cytochemical characteristics of peroxisomes have been identified in the satellite and Schwann cells of rat dorsal root ganglia. They are membrane-delimited, round or oval structures which contain a moderately electron-dense matrix but lack a crystalline core. On incubation of the tissue in a cytochemical medium for demonstration of peroxisomes, these bodies show ...
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7 8 Neuroscience and Mental Health Institute and Department of Pharmacology or Physiology 9 Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada T6G 2H7, 10 11 12 Manuscript properties: 10 Figures; 2 Tables; Abstract 245 words; 13 14 15 Running Header: Neuron type specific actions of gabapentinoids 16 17 18 Corresponding author: 19 20 P.A. Smith, 21 Department of Pharmacol...
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ژورنال
عنوان ژورنال: Acta Neuropathologica Communications
سال: 2016
ISSN: 2051-5960
DOI: 10.1186/s40478-016-0288-5